Three-Spice Combo Improves Chronic Knee Osteoarthritis

By GreenMedInfo Research Group

Turmeric extract, when combined with gingerols in ginger and piperine in black pepper, shows promise for addressing osteoarthritis, with results similar to those  achieved by a common anti-inflammatory medication

Osteoarthritis is a degenerative joint disorder that is the leading cause of disability in the elderly and a major contributor to chronic, debilitating pain.[i] It is a challenging disease with limited treatment options.

While medications like nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen and opioids are widely used to relieve osteoarthritis pain, they usually come with side effects and are unable to reverse the cartilage damage that underlies this condition. This has positioned curcumin, the active ingredient in the spice turmeric, as a strategic way to address the inflammation and protect the joints.

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A study further investigated curcumin and its effectiveness for knee osteoarthritis when paired with beneficial ingredients in ginger and black pepper, with promising results.[ii]

Spice Combo Works as Well as Drug Treatment

An August 2020 study investigated curcumin when combined with gingerols in ginger and piperine in black pepper, which may enhance and sustain its effect against the disorder, compared with the drug Naproxen.[iii]

The study subjects were randomly assigned to receive turmeric extract, ginger and black pepper together or Naproxen for four weeks. The results indicate that taking the three-spice combo twice daily for four weeks improved prostaglandin E2 (PGE2), a primary inflammatory mediator in osteoarthritis, levels similar to Naproxen. PGE2 decreased significantly in both groups, without any substantial difference between them.

A previous study found that over half of osteoarthritis pain studies and more than 80% of industry-funded ones used trial durations of less than six months.[iv] This despite the fact that the disorder and resulting chronic pain are progressive and represent a long-term burden on patients and health care systems.

Previous studies have also explored the role of curcumin in treating osteoarthritis. In one study involving patients with moderately severe symptoms that required treatment with an NSAID, the subjects were given the NSAID diclofenac — 50 milligrams (mg) twice daily — or curcumin, 500 mg three times daily.[v] Both treatments relieved arthritis symptoms and helped to a similar degree, with curcumin users reporting fewer side effects.

Sound Alternatives to Painkillers

There has been growing public awareness of the adverse effects linked to synthetic painkillers, thus providing the need for natural and evidence-based alternatives. Here are four clinically validated, natural alternatives that are worth considering for osteoarthritis and other sources of chronic pain:

  1. Arnica — In a 2007 study, topically applied arnica was found to be as effective as ibuprofen for relieving symptoms due to osteoarthritis of the wrist.[vi] It also led to fewer side effects.
  2. Thyme — A 2004 study found that thyme extract worked as effectively as ibuprofen in decreasing pain and spasm symptoms associated with dysmenorrhea, or menstrual cramps.[vii]
  3. Omega-3 fatty acids — In a 2006 study, omega-3 supplementation reduced neck and back pain patients’ need for pain medications, along with improving their overall pain and joint pain.[viii] The subjects saw results consistent with previous research, indicating outcomes at least as effective as ibuprofen.
  4. Cinnamon — A 2015 study concluded that cinnamon was as effective as ibuprofen for menstrual  pain.[ix]

The database offers more than 3,000 abstracts related to turmeric research, as well as databases on natural anti-inflammatories and analgesics.




[i] Zhang W et al “Current research on pharmacologic and regenerative therapies for osteoarthritis” Bone Res. 2016; 4: 15040. Epub 2016 Mar 1.

[ii] Heidari-Beni M et al “Herbal formulation”turmeric extract, black pepper, and ginger versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial” Phytother Res. 2020 Aug ;34(8):2067-2073. Epub 2020 Mar 16.

[iii] Heidari-Beni M et al “Herbal formulation”turmeric extract, black pepper, and ginger versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial” Phytother Res. 2020 Aug ;34(8):2067-2073. Epub 2020 Mar 16.

[iv] Losina E et al “Studies of Pain Management in Osteoarthritis: Bedside to Policy” Osteoarthr Cartil. 2013 Sep; 21(9): 10.1016/j.joca.2013.04.013.

[v] Shep D et al “Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study” Trials. 2019; 20 (214).

[vi] Widrig R et al Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study” Rheumatol Int. 2007 Apr;27(6):585-91. Epub 2007 Feb 22.

[vii] Salmalian H et al Comparative effect of thymus vulgaris and ibuprofen on primary dysmenorrhea: A triple-blind clinical study” Caspian J Intern Med. 2014 ;5(2):82-8.

[viii] Maroon J et al “Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain” Surg Neurol. 2006 Apr;65(4):326-31.

[ix] Jaafarpour M et al “Comparative Effect of Cinnamon and Ibuprofen for Treatment of Primary Dysmenorrhea: A Randomized Double-Blind Clinical Trial” J Clin Diagn Res. 2015 Apr; 9(4): QC04–QC07. Epub 2015 Apr 1.

Source: GreenMedInfo

This article is copyrighted by GreenMedInfo LLC, 2020
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The GMI Research Group (GMIRG) is dedicated to investigating the most important health and environmental issues of the day.  Special emphasis will be placed on environmental health.  Our focused and deep research will explore the many ways in which the present condition of the human body directly reflects the true state of the ambient environment.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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