Molecular Hydrogen for Cancer and other Diseases


By Dr. Mark Sircus

Scientific researchers tell us, “Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell.”[1]

In terms of medicine small is good, as Nano science has tended to show. In the case of hydrogen, we are talking about the ultimate in smallness proving to be the biggest medical breakthrough of the 21st century. Hydrogen appears in the top left corner of the periodic table, and is denoted as number one. Hydrogen is the smallest, simplest, and most fundamental element with molecular hydrogen (H2) the smallest molecule.

Interestingly, water, which is essential to life, is formed by the combination of oxygen (a powerful oxidizer) and hydrogen (a powerful reducer).  It tends to make sense that molecular hydrogen has high-powered therapeutic potential as does water itself. Hydrogen is a novel and innovative therapeutic tool and can be used like intravenous vitamin C therapy except it is vastly less expensive, and can be used every day around the clock—with every sip of water.

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Each drink of hydrogen water will flush our bodies with trillions of hydrogen molecules. H2 is an effective molecule to scavenger or pair up with toxic hydroxyl radicals in the body that need to be neutralized. Hydrogen therapy is safe as there is no upper limit of use. The more water you drink infused with hydrogen the better, especially if you have late stage cancer and need to turn things around quickly.

Each drink of hydrogen water will flush our bodies with trillions of hydrogen molecules. H2 is the most effective molecule to scavenger or pair up with other molecules in the body that need to be neutralized. Hydrogen therapy is safe as there is no upper limit of use. The more water you drink infused with hydrogen the better, especially if you have late stage cancer and need to turn things around quickly.

There is no toxicity to H2 because the byproduct of the free-radical neutralizing reaction is water. Each molecule of H2 will neutralize 2 hydroxyl radicals into two molecules of H2O hydrating your cells in the process. Hydrogen water at a concentration of 1.6 mg/L would have more “antioxidant” molecules than 100 mg of vitamin C, as there are more total molecules in 1.6 mg of hydrogen compared 100 mg of vitamin C.


Now, one can have 2 ppm (2.0 mg/L) of hydrogen infused water by dropping an Active H2 tablet in a ½ liter bottle of water. If you use a smaller 12 oz. bottle of water, the concentration is even higher. With late stage cancer and many other medical emergencies one would want to drink water with the highest hydrogen concentration available. As a medicine, doctors will obviously favor molecular hydrogen in tablet form for ease of administration and higher concentration.

Molecular hydrogen is a medical leap that is going to help many people. It elevates oral medicine to the level of intravenous medicine because of the ultra-quick absorption and dispersion deep into the cells. Now water can become the ultimate medicine especially if some of some of my other health solutions (magnesium, bicarbonate, iodine and liquid selenium) are used, when appropriate.

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Medical/therapeutic water high in hydrogen will ride to the rescue of doctors and patients who are battling with chronic diseases. Studies have confirmed that consumption of hydrogen reduces oxidative stress in a diverse range of disorders and organ systems including the digestive, cardiovascular and respiratory systems. There are hundreds of scientific publications that show molecular hydrogen to be therapeutic. Even NASA is researching hydrogen water to protect their astronauts from radiation during space travel.

Hydrogen is intriguing. As explained by Tyler LeBaron, founder of the Molecular Hydrogen Foundation, hydrogen powers the sun’s fusion, it is key to ATP production within the mitochondria, and it is the father of all other elements. Hydrogen, along with oxygen, has been intrinsically involved with evolution of life in both prokaryotes and eukaryotes (e.g. hydrogenases, hydrogenosomes, mitochondria, etc.). The extremes of oxygen and hydrogen provide balance between oxidation and reduction, which is vital to life. The most important and basic thing to know about molecular hydrogen is that it negates the toxicity of oxygen.

Hydrogen in the body is mostly bound to carbon, oxygen and nitrogen. It is part of almost every molecule in your body: DNA, proteins, sugars, fats. The hydrogen bond – which forms between atoms that “share” a hydrogen atom, is one of the most important interactions that makes biological molecules behave as they do. Thus, hydrogen is an important factor in the regulation of physiology.

Molecular Hydrogen is an ideal antioxidant molecule for oxidative stress in the mitochondria due to its small size. It is one of the very few, if not only antioxidant molecules that can reach the inside of the mitochondria. H2 directly protects mitochondria that are exposed to reactive oxygen species. Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders. Drinking H2-water stimulates energy metabolism as measured by O2 consumption and CO2 production.

This is what I would call the ultimate testimony from a doctor about what you can expect if we start supplementing with the hydrogen.

Antioxidant, Antitumor Cancer Treatment

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. H2 selectivelyreduces the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H2 does not react with other ROS, which possess physiological roles. The inhalation of H2 gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus, H2 can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.[2]

ROS are involved in metastatic processes including invasion of cancer cells into surrounding primary tumor sites.  Generated ROS regulates tumor progression, indicating that ROS is situated upstream in many signaling pathways including the pathway involved in metastasis. At tumor sites, large amount of ROS are produced by activated neutrophils and macrophages in the inflammatory response.

Hydrogen water erases ROS indispensable for tumor cell growth. Scientists who have studied its antitumor effects used hydrogen in combination with hyperthermia at 42°C and found it to be potent as an anti-tumor agent.[3]Therapeutic opportunities of hydrogen increases in the presence of specific catalysts or heat thus for cancer and other serious diseases it should be used in the context of a full protocol.


H2Bev is one of the first prepackaged molecular hydrogen products. It provides approximately 1 ppm of H2 and includes a variety of B-vitamins and Erythritol. Despite its comparatively high-ticket price (about 4 times that of the tablets with shipping) it is ready to drink immediately (best served chilled) from its special aluminum container. H2Bev makes a great lifestyle product for non-therapeutic use though its effects are still noticeable.

Active H2 tablets (60) are only $1.00 per dose. The concentration of one tablet of Active H2 in 1/2 liter of water is over 2 ppm if it is prepared properly (fill bottle to the top, drop in tablet, allow to react for 15 minutes, put in the refrigerator until well-chilled). But if you put the tablet into a 12oz H2Bev bottle you will have almost 2.7 ppm!

One tablet is sufficient for everyday general use and two tablets for more demanding active lifestyles. Heavy therapeutic dosing would imply three or more tablets a day for three months if one were a late stage cancer patient or someone else fighting a serious life-threatening disease. One might want to entertain purchasing a new generation of neutral-pH ionizer specifically designed to make hydrogen infused water – soon to come into the market. The early models do not match the H2 concentration of tablets but they will improve over time. Expect the best ones to be pricey.

Water Ionizers Produce Hydrogen Water

It is very revealing that it is not the high pH alkaline water that provides health benefits but the molecular hydrogen – but only if the ionizer electrodes are brand new or perfectly free of scale and you drink the water right away. Otherwise, the H2 will outgas quite quickly. In other words, the hydroxide ion (OH-) is NOT responsible for most of the positive effects observed when drinking alkaline ionized water. The active antioxidant is dissolved molecular hydrogen (H2). The highest quality lower cost ionizer from a reputable company offers a sizable discount if you mention who referred you.

Not all ionizers make sufficient H2 to be considered even “low level,” in terms of hydrogen concentration,  as the electrolytic plates become scaled or fouled, they stop make H2 completely. Importantly, the ionizer above is one of the few that reverses the electrodes for cleaning whenever the unit has not been used for 6 hours to make sure the hydrogen concentration is constantly as high as possible. Unless ionizers have a self-cleaning feature to prevent scale and impurities from coating the electrolysis plates, the H2 concentration drastically reduces in a short time.  If one is in doubt, it is good to measure the amount of hydrogen with a test kit available from

The Molecular Hydrogen Foundation says, “The hydrogen gas concentration from water ionizers various significantly from less than 0.05 ppm to over 2.5 ppm depending on source water, flow rate, design, and cleanliness of the electrodes. Importantly alkaline water ionizers were developed decades before it was known of the therapeutic importance of molecular hydrogen, thus these units were optimized for alkaline pH not high dissolved hydrogen concentration. Typically, at normal flow and normal source water the concentration of H2 from an alkaline water ionizer is around 0.1 ppm to 0.7 ppm. By running the water very slowly, these machines may increase the molecular hydrogen concentration.”

Hydrogen, Inflammation and Pain

The cells that are repeatedly exposed to inflammatory mediators will have the genes that code for inflammatory response proteins switched on, and thus be in a constant state of inflammation. This leads to diseases and health conditions that are strongly linked to inflammation, including asthma and cardiovascular diseases. Some of the molecules in the body that can instigate a change in gene expression are: Nf-kB, TNFa, and reactive nitrogen species such as nitric oxide and peroxynitrite.

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Hydrogen indirectly affects gene expression through its actions to modulate molecules that have a direct epigenetic effect, Molecular Hydrogen can:

· Impede release of NF-kB

· Reduce TNFa

· Reduce excess nitric oxide

· Scavenge peroxynitrite

Molecular hydrogen has been shown to be an anti-inflammatory in acute conditions, but it is also a potential epigenetic modifying agent for genes that code for chronic pain and inflammation.


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Molecular Hydrogen is the newest addition to my Natural Allopathic protocol and will probably be in the number one slot because His the ultimate hydration and recovery drink. Will be updating my Water Based Medicine book with hydrogen water. It should always be remembered when reading information about any medicinal that a combination of medicinals, a protocol approach, is always best when one attempts healing from a serious disease.


[1] Med Gas Res. 2013; 3: 10. Published online 2013 May 16.doi:10.1186/2045-9912-3-10The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance. Brandon J Dixon,1Jiping Tang,1andJohn H Zhangcorresponding author1,2

[2] Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ikuroh Ohsawa1, Masahiro Ishikawa1, Kumiko Takahashi1, Megumi Watanabe1,2, Kiyomi Nishimaki1, Kumi Yamagata1, Ken-ichiro Katsura2, Yasuo Katayama2, Sadamitsu Asoh1 & Shigeo Ohta1

[3] Oncol Rep.2010 Dec;24(6):1463-70. Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Asada R1,Kageyama K,Tanaka H,Matsui H,Kimura M,Saitoh Y,Miwa N.

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