13 of The Most Effective Mood Stabilizers in Natural Medicine

By Dave Mihalovic

Pharmaceuticals prescribed for mood are among the most dangerous due to their side effects and high toxicity to brain chemicals and hormones. Medicinal plants and natural nutrients are extremely effective in promoting neurotransmitter balance while promote relaxation. Here are 13 of the most effective mood stabilizers in natural medicine.

Mood-stabilizing drugs are purely antimanic agents, which are mainly for treating mania. From this perspective, they are quite different from antidepressants, which are also called mood enhancers, elevators, or boosters in treating depression. Natural mood stabilizers help the body metabolize those chemicals which enhance mood, something drugs can never do due to specific metabolic pathways necessary to metabolize the chemical constituents.

Unlike pharmaceuticals, natural mood stabilizers:

  • Treat effectively or prevent manic symptoms;
  • Won’t aggravate depressive symptoms, and improve or even preventing depressive symptoms;
  • Stabilize moodswings, suppressing manic phases but not inducing depression and curing depressive episode while not causing mania;
  • During supplementation with natural mood stabilizers, there are no major side effects or complicated states such as mixed episodes of mania and depression, mixed multiple mental diseases, and rapid mood cycling and shifting;
  • Won’t increase suicide risk or psychosis.

1) Ginseng

Ginseng can have several advantages for health including mood. There are three ginseng herb species, but the most important of the three are Asian (Panax) ginseng and American ginseng (Panax quinquefolius ). These herbs are shown to have the most advantages for people who need to improve their mood. Ginseng has also been shown to inhibit tumor growth, relieve symptoms of diabetes and boost the immune system. Ginseng is available in several forms, and is available over-the-counter without a prescription. Ginseng is available in extracts, liquid or pill form.

2) DMG

An important supplement that can be obtained naturally from diet, the molecule is part of a group of important chemicals called methyl donors. This chemical structure is essential to the body, and plays many important roles. The bodys ability to attach a methyl group to another molecule enhances enzyme production, chemical metabolism, as well as mood and energy levels. For DMG to work optimally biochemically, folate intake and levels in the body must be adequate . DMG is noted to increase physical stamina and energy levels. In children, it has been seen to increase attention span and decrease irritability.

3) 5-HTP

Building block to the neurotransmitter Serotonin, which regulates mood balance. 5-HTP is a derivative of the amino acid L-Tryptophan, which is both produced by the body and found in high-protein foods such as dairy products, fish, poultry and other lean meats. The supplement form of 5-HTP is naturally extracted from the seeds of Griffonia simplicifolia, a tree native to the Ivory Coast and Ghana. 5-HTP is a nutrient that acts as a building block for the neurotransmitter Serotonin and may help to promote healthy neurotransmitter balance following daily use for two to six weeks.

4) Lavender

Lavender is a common herb used in aromatherapy for mental health and mood. Lavender is a part of aromatherapy for headaches and depression. Lavender is a part of several scented products like perfumes soaps, shampoos and sachets. The plant is usually extracted into an oil and used in aromatherapy for mood, stress and anxiety. Lavender should be used with the recommendation of a physician, because it can interact with other medications.

5) St. John’s Wort

Natural reuptake inhibitor that supports a healthy neurotransmitter balance. St. John’s Wort is an aromatic perennial herb with an abundance of golden-yellow flowers. Tiny perforations filled with phytochemical-rich oils cover the aerial (above- ground) portions of St. John’s Wort and yield an extract that gives the plant its primary health benefits. Current usage statistics indicate that millions of Americans supplement their daily diets with St. John’s Wort to promote positive mood balance. The medicinal components of St. John’s Wort, which include Hypericin and Hyperforin, have been clinically shown to promote a healthy neurotransmitter balance, which can help to provide positive mood support following two to six weeks of continued use.

6) L-Threonine

The Princeton Brain Bio Institute found that low levels of the essential amino acid threonine have been found in people with depression, they found that increasing threonine levels could help improve mood. Sesame seeds in all shapes and forms are one of the best food sources of this nutrient. It supports cardiovascular, liver, central nervous, and immune system function. L-threonine has been researched for ALS because it affects glutamate metabolism.

7) Kava Kava

Kava kava is a root that is used to relax and soothe mood. Kava is found in tea or in pill form, and it can be purchased at a local vitamin shop or health food store. Kava grows in the South Pacific and is used for medicinal purposes including mood and insomnia. Kava is found in pills to help patients with anxiety, but it’s also known for its ability to help addicts through withdrawal symptoms that include insomnia. Kava improves mood for people, helping them reduce anxiety during withdrawal. Kava should be taken with caution, since it has been shown to harm the liver when taken in excess.

8) SAM-e

Natural reuptake inhibitor used to support a healthy neurotransmitter balance. SAM-e (pronounced “sammy”) is a naturally occurring chemical that performs a wide range of functions throughout the body. In clinical study, SAM-e supplementation has demonstrated a broad spectrum of action to stimulate neurotransmitter productivity and maintain healthy cell-to-cell communication. Italian researchers discovered the benefits of SAM-e in the 1970s, when they observed it to have significant effects on individuals experiencing mood changes. SAM-e has been available over the counter in the United States since 1996, and is widely used as a dietary supplement to provide positive support for depressed mood and mild to moderate mood changes caused by everyday stress, including occasional nervousness, nervous tension and anxiety.


Considerable evidence implicates the neurotransmitter aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. Animal models of depression show regional brain GABA deficits and GABA agonists have antidepressant activity in these models. he balance between the limbic system, and in fact, the rest of the brain to communicate in an orderly manner depends critically on inhibition. GABA inhibits the cells from firing, diminishing the anxiety-related messages from reaching the cortex. GABA, glutamine and glycine are vital for energy and the smooth running of the brain functions. B6 (pyridoxine) is GABA’s most important partner.

10) R-Alpha Lipoic Acid

R-Alpha Lipoic Acid is made by the human body and its levels drop by age. There are functional differences between endogenous (produced by the body) and exogenous (from supplements): Endogenous R-Alpha Lipoic Acid is bound to proteins, whereas the exogenous (supplemental) is unattached and easily goes into circulation. Both spatial and temporal memory improves with R-Alpha Lipoic Acid supplementation and oxidative damage to the hippocampus of the brain decreases. It has been said that the Acetyl-L-carnitine/alpha-lipoic acid combo may also protect from neurodegeneration or cognitive impairment. This combination also shows great potential for neurological repair in diseases such as: age related dementia; Amyotrophic lateral sclerosis (ALS), which is better known as Lou Gehrig’s disease; Alzheimer’s disease (AD); and Multiple sclerosis (MS), which is also known as “disseminated sclerosis” or “encephalomyelitis disseminata.”

11) Passion Flower

Natural sedative relieves occasional anxiety and mild panic attacks. Passion Flower is a woody vine that bears small berry-like fruit calledgrandilla. The brightly colored flowers and above-ground portions of the Passion Flower vine are used to derive medicinal compounds that relax the central nervous system and promote emotional balance. In the United States, Passion Flower is classified as GRAS (Generally Recognized as Safe) by the Food and Drug Administration. Substances that receive a GRAS classification have maintained a long, safe history of common use in foods or have been determined to be safe based on proven scientific research.

12) Winter Cherry

Relieves nervous tension, occasional anxiety and mental fatigue. Winter Cherry, or Ashwagandha Root, is among the most prominent herbal preparations used in Ayurveda, a holistic system of medicine that originated in India. The root of this small evergreen shrub is primarily recognized for its adaptogenic properties, meaning it naturally increases the body’s resistance to physical and emotional stress. Practitioners of Ayurveda traditionally prescribe Winter Cherry to promote gentle relaxation and emotional balance. Research has shown that Winter Cherry is a safe, natural sedative that produces the most noticeable benefits following daily use for two to six weeks.

13) Arctic Root
(Rhodiola Rosea)

Relieves occasional anxiety and positively supports the body during periods of stress. Arctic Root is a plant indigenous to Siberia, where it thrives in high altitudes and dry arctic climate. The primary medicinal compounds of Arctic Root are derived from the root of the plant.

In Russia, Scandinavia and much of Europe, Arctic Root has been traditionally recognized for its adaptogenic properties. An adaptogen is a physiological agent that naturally increases the body’s resistance to physical and emotional stress. Rhodiola Rosea has been clinically shown to stimulate Serotonin, Norepinephrine and Dopamine activity, and may help to support healthy neurotransmitter balance.


Contains: Acetyl-L-Carnitine, R-Alpha Lipoic Acid, Pantothenic Acid, Co-enzyme Q10, methylcobalamin, DMG, GABA, L-Tyrosine, L-Threonine.

This formulation is a vast improvement over any other for its bioavailability with added the patented Sigma-Tau’s Acetyl-L-Carnitinewith advanced delivery, complete with clinical studies showing the effectiveness of this material opposed to other forms of Acetyl-L-Carnitine.

Instead of using DL-Alpha Lipoic Acid, instead the Life Choice Neurotransmitter Support uses R-Alpha Lipoic acid. This formulation matches the same two principle ingredients used in the clinical Study of Berkley School of Medicine and from that stage Life Choice created an even more advanced delivery with the unknown amino acid L-Threonine, not to be confused with L-Theonine.

Through research and investigation, Life Choice have further advanced the relationships between neurological biochemistry and bioavailability for an ingestible supplement.

This advanced formulation is a breakthrough for increasing energy, memory, neuronal activity and mental clarity either taken for prevention and or recovery of declining brain activity.
Dave Mihalovic is a Naturopathic Doctor who specializes in vaccine research, cancer prevention and a natural approach to treatment.

  • Anonymous

    vitamin b complex isnt even mentioned nor was magnesium (good nights sleep stabilizes your mood)

  • Anonymous

    what about marijuana?

  • Anonymous

    Pycnogenol seems to have some effect.

  • Anonymous

    Marijuana? For people with unstable moods, marijuana can be the worst thing to do. Paranoia and anxiety are common reactions to marijuana. Marijuana is not a mood stabilizer. It's actually a depressant.

  • a shot or 2 of Jack sure makes me happier after a hard week of work..? lol

  • Anonymous

    Good point. Insomnia isn't caused because your body lacks winter cherry, kava kava, or some other root. If you suffer from insomnia, your best treatment is B complex and magnesium (along with a good multi – and vitamin D from sunshine is also important).

  • Anonymous

    Magnesium is the biggest omission here, as others have noted. It immediately lifts the profoundest depression, and yes, depression IS caused by a lack of it, which is not surprising as soils are increasingly depleted and foods are increasingly being supplied to us in a processed form.
    Mg acts at the NMDA receptor in the neuron. It physically blocks calcium from entering the cell; if calcium gets in, the cell cannot reach its normal electrical potential, and so it does not fire. result; depression.
    Mg is also the mineral having the biggest effect of ANY known substance on neuroplasticity, ie the ability to learn and preserve new memories; it acts primarily on the cells in the hippocampus to achieve this. It regulates and stabilizes the heart rhythm, it lowers BP, and lowers cholesterol by directly inhibiting the HMG-CoA reductase enzyme which statins destroy. It binds to ATP synthase and allows energy to be injected into the cell. It facilitates sleep, as noted above.
    It is very cheap. Ancient Minerals supply it in bulk crystal form; dilute down and take 400mg morning and night. The dose is divided as Mg can have a laxative effect; its only known side-effect at this sort of doseage.

  • Some of the items on this list are not "mood stabilizers" they are natural anti-depressants that DO have the potential for causing mania and increased suicidality. SAM-e products even include a warning for people with bipolar for this. 5- HTP and St. John's Wort can also be potentially dangerous. Do more research and rewrite your article Mr Mihalovic, it's a bit off.

  • Anonymous

    Where did you get your information? Medical marijuana is being prescribed to people for depression and mood disorders because of it's benefits. I'm talking about the medical kind, not the "smoke a joint" kind.

  • Anonymous

    I believe you are describing an amino acid called L-Theanine. Please research and adjust your article.

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